Yellow, red, and greenish autumn leaves with a vaccine syringe and vial posed against a white background; concept is fall vaccines

The fall calendar doesn’t just warn us of impending cold temperatures: It also points toward seasonal upticks in cases of RSV (respiratory syncytial virus), COVID, and influenza. These respiratory viruses were dubbed a “tripledemic” last year. After they collided to overload health care systems across the country, hospitalizations rose in tandem for all three illnesses over the fall and winter months.

Warding off severe cases — which may lead to hospitalization or death — should be top of mind, especially for those who are most vulnerable, a Harvard expert says. And updated versions of all three vaccines are now available to help protect us.

Why do cases of flu, RSV, and COVID typically rise in fall?

“This is typically the time of year we start to see viral infections increase, which has a lot to do with kids going back to school,” says Dr. John Ross, an assistant professor of medicine at Harvard Medical School who is board-certified in infectious diseases.

“Also, we’re starting now to have weather that’s more favorable for viral transmission, particularly lower humidity. Viruses survive better in dry air. And drier air also affects our airways and makes them more vulnerable to being infected.”

Who is eligible for each shot?

Eligibility recommendations vary by age and vulnerability to serious illnesses. Additionally, some shots are designed to help protect specific groups against serious illness.

The CDC recommends these shots for the following groups.




Who is likely to benefit most?

Getting the right vaccines can help people avoid missed work or school days and running the risk of making others sick. And the protection offered by these shots is especially important for certain groups.

For all three viruses, the people most vulnerable to severe illness are similar, Dr. Ross says, including

“Certainly with COVID and flu, pregnancy outcomes are worse with those infections,” Dr. Ross says. “I’m not saying that RSV isn’t a risk for pregnant mothers, but there’s not much data. The reason pregnant women are offered RSV vaccination is so the maternal antibodies they produce protect the newborns, because they’re at very high risk for RSV with very bad outcomes.”

Additionally, an even wider range of people are more prone to complications from the flu, according to the CDC. This includes

What else should you know about flu, COVID, and RSV shots?

Beyond broad guidance determining who’s eligible for each type of vaccine, Dr. Ross offers other useful insight that may guide your choices.

When is the best time to get a flu shot?

The CDC recommends getting a flu shot in September or October, and Dr. Ross agrees. “These are usually the months the flu vaccine becomes available and vaccine clinics are easiest to find,” he says. “My personal approach is just to get the vaccine when it’s available, so you don’t forget.”

Will the updated COVID vaccines protect against newer strains of the virus?

The latest mRNA shots by drugmakers Pfizer and Moderna are monovalent, meaning they protect against one variant — XBB.1.5, the most recent to descend from Omicron earlier in 2023. Though that strain is no longer dominant, the boosters should still guard against closely related subvariants that are now circulating, Dr. Ross says. “People can feel comfortable about their protection regardless,” he says.

What else should I know about RSV shots?

The version meant for infants, Beyfortus, isn’t a vaccine at all. It’s a monoclonal antibody product that directly delivers antibodies that protect babies for the duration of a single fall-winter RSV season. These antibodies can prevent RSV or lessen its severity.

Dr. Ross says adults over 60 considering RSV vaccination should be aware of the potential for two rare but potentially serious side effects of the nervous system: the autoimmune conditions Guillain-Barre syndrome and acute disseminated encephalomyelitis, or ADEM. Guillain-Barre can lead to bodywide paralysis, while ADEM can cause weakness and seizures. The risk of these side effects after RSV vaccination in adults is about one in 7,000 — far higher than occurs after flu vaccination, Dr. Ross notes.

“If you’re a totally healthy 60-year-old, I’m not sure it makes sense to get the RSV vaccine,” he says. “It’s a conversation you should have with your doctor.”

How should I schedule shots if I’m getting several vaccines?

Research suggests that it’s safe to get both flu and COVID vaccines at the same time. Reactions (such as muscle aches, fatigue, and headache) are slightly higher when flu vaccine and an mRNA COVID vaccine are combined, according to one study, though these reactions usually are mild and disappear quickly.

“Because RSV vaccines are newer, I don’t think we know much about combining these shots with other vaccines,” says Dr. Ross. Scheduling this vaccine separately is a good idea, although you should talk to your doctor about potential risks and benefits for your situation.

About the Author

photo of Maureen Salamon

Maureen Salamon, Executive Editor, Harvard Women's Health Watch

Maureen Salamon is executive editor of Harvard Women’s Health Watch. She began her career as a newspaper reporter and later covered health and medicine for a wide variety of websites, magazines, and hospitals. Her work has … See Full Bio View all posts by Maureen Salamon

About the Reviewer

photo of Howard E. LeWine, MD

Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing

Dr. Howard LeWine is a practicing internist at Brigham and Women’s Hospital in Boston, Chief Medical Editor at Harvard Health Publishing, and editor in chief of Harvard Men’s Health Watch. See Full Bio View all posts by Howard E. LeWine, MD

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